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For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Synthetic heptapeptide (tuftsin analog)
Molecular formula
C33H57N11O9
Molecular weight
751.88 g/mol
CAS number
129954-34-3
Amino acids
7
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Modification
Free termini; tuftsin (Thr-Lys-Pro-Arg) extended with a C-terminal Pro-Gly-Pro motif to confer protease resistance. N-Acetyl Selank adds N-terminal acetylation as a further stability modification.
Mechanism & Target Class
Mechanism & Target Class
A linear heptapeptide analogue of the immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), extended at the C-terminus with a Pro-Gly-Pro motif reported to confer resistance to peptidase cleavage. Research on the parent compound describes several studied mechanisms: concentration-dependent inhibition of enkephalin-degrading enzymes in human serum, examined in relation to endogenous enkephalin hydrolysis; modulation of GABAergic-system gene expression studied at the transcriptional level; effects on monoamine systems (serotonin, dopamine, norepinephrine) measured by HPLC in brain structures; and regulation of BDNF expression and cytokine/chemokine gene expression. N-Acetyl Selank is the N-terminally acetylated variant; its pharmacological properties are inferred from parent-compound studies, as no dedicated peer-reviewed literature exists for the acetylated form.
Storage & Handling
Storage & Handling
Lyophilized
20°C, protected from light and moisture
stable long term.
Hydrophilic and water-soluble; aliquot to avoid repeated freeze-thaw cycles; protect from light.
References
References
Reviews
- 1
Deigin VI, Poluektova EA, Beniashvili AG, Kozin SA, Poluektov YM. (2022). Pharmaceutics
- 2
Kolomin T, et al. (2018). Protein Pept Lett
Reviews
- 3
Kolomin TA, et al. (2019). Biology Bulletin
Clinical
- 4
Panikratova YaR, et al. (2020). Doklady Biological Sciences
- 5
Medvedev VE, Tereshchenko ON, Israelyan AYu, Chobanu IK, Kost NV, Sokolov OYu, Myasoedov NF. (2014). Zh Nevrol Psikhiatr Im S S Korsakova
- 6
Zozulia AA, et al. (2008). Zh Nevrol Psikhiatr
- 7
Uchakina ON, et al. (2008). Zh Nevrol Psikhiatr
Primary research
- 8
Filippenkov IB, Glazova NYu, Sebentsova EA, et al. (2024). Nanobiotechnology Reports
- 9
Konstantinopolsky MA, Chernyakova IV, Kolik LG. (2022). Bull Exp Biol Med
- 10
Kolik LG, Nadorova AV, et al. (2019). Bull Exp Biol Med
- 11
Povarov IS, Kondratenko RV, Derevyagin VI, Myasoedov NF, Skrebitsky VG. (2017). Bull Exp Biol Med
- 12
Filatova E, Kasian A, Kolomin T, Rybalkina E, Alieva A, Andreeva L, et al. (2017). Front Pharmacol
- 13
Volkova A, et al. (2016). Front Pharmacol
- 14
Kolomin T, et al. (2014). Molecular Immunology
- 15
Kolomin TA, et al. (2014). Neuroscience and Behavioral Physiology
- 16
Solov'ev VB, Gengin MT, et al. (2012). J Evol Biochem Physiol
- 17
Kolomin TA, Shadrina MI, Agniullin YaV, et al. (2010). Doklady Biochemistry and Biophysics
- 18
Andreeva LA, Ershov FI, et al. (2009). Vopr Virusol
- 19
Semenova TP, Kozlovskii II, Zakharova NM, Kozlovskaia MM. (2009). Eksp Klin Farmakol
- 20
Narkevich VB, et al. (2008). Eksp Klin Farmakol
- 21
Inozemtseva LS, Karpenko EA, Dolotov OV, et al. (2008). Doklady Biological Sciences
- 22
Semenova TP, Kozlovskaya MM, Zuikov AV, et al. (2008). Neuroscience and Behavioral Physiology
- 23
Zolotarev YuA, Sokolov OYu, Kost NV, et al. (2004). Russian Journal of Bioorganic Chemistry
- 24
Kozlovskaya MM, Kozlovskii II, Val'dman EA, Seredenin SB. (2003). Neuroscience and Behavioral Physiology
- 25
Sokolov OYu, Meshavkin VK, Kost NV, Zozulya AA. (2002). Bull Exp Biol Med
- 26
Kost NV, Sokolov OYu, Gabaeva MV, et al. (2001). Russian Journal of Bioorganic Chemistry
- 27
Kost NV, et al. (2001). Bull Exp Biol Med
Primary Database
Primary Database
- Jun 9, 2026Debra R.Verified
Received the product well packaged with protective inserts.
The QR code on the vial scanned directly to the batch-specific third-party COA. Lot numbers aligned without discrepancy. Support had answered a pre-order specification question the same day. Documentation was thorough and professional.
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
