Cognitive
A peptide studied in cognitive and neurological research models.
Semax is studied in brain and cognition research. Derived from a fragment of the natural ACTH hormone (but without its stress-hormone activity), it is examined in preclinical models for how it may relate to memory, focus, and the protection of nerve cells, partly through its effect on brain growth factors such as BDNF and NGF.
Type
Synthetic peptide (heptapeptide)
Molecular formula
C37H51N9O10S
Molecular weight
813.93 g/mol
CAS number
80714-61-0
Amino acids
7
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Modification
Free termini; ACTH(4-7) extended with a C-terminal Pro-Gly-Pro motif.
A linear heptapeptide consisting of the ACTH(4-7) fragment extended with a Pro-Gly-Pro motif that resists enzymatic degradation. A non-corticotropic ACTH-fragment analogue; research characterizes its interactions with neurotrophin systems.
Research Focus
Studied in neuroprotection, neurotrophic-factor (BDNF/NGF) and cerebral-ischemia research models.
Lyophilized
-20°C, protected from light and moisture
stable long term.
Reconstituted
2-8°C short term
-20°C for longer aliquots.
The methionine residue is oxidation-susceptible; protect from light/air; avoid freeze-thaw.
Reviews
Tsai SJ. (2007). Medical Hypotheses — Review of dopamine and BDNF modulation
Clinical
Gusev EI, et al. (2018). Zh Nevrol Psikhiatr — Clinical study in ischemic-stroke patients examining outcome measures and plasma BDNF
Lebedeva IS, et al. (2018). Bull Exp Biol Med — Resting-state fMRI study of the default mode network
Gusev EI, et al. (1997). Zh Nevrol Psikhiatr — Early clinical and electrophysiological study in acute ischemic stroke
Primary research
Sudarkina OY, et al. (2021). Int J Mol Sci — Brain protein-expression profiling in cerebral ischemia-reperfusion (rat tMCAO)
Medvedeva EV, et al. (2014). BMC Genomics — Genome-wide transcriptional analysis in focal ischemia (rat pMCAO)
Dolotov OV, et al. (2006). J Neurochem — Specific-binding and BDNF-level study in rat basal forebrain
Levitskaya NG, et al. (2004). Neurosci Behav Physiol — Behavioral study in an MPTP dopaminergic-lesion model (rat)
Also known as: ACTH(4-7)-Pro-Gly-Pro
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
