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Out of StockMolecular Profile
Molecular Profile
Type
Synthetic peptide (heptapeptide)
Molecular formula
C37H51N9O10S
Molecular weight
813.93 g/mol
CAS number
80714-61-0
Amino acids
7
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Modification
C-terminal Pro-Gly-Pro tripeptide extension of the ACTH(4-7) core; confers resistance to prolyl endopeptidase degradation; PGP is the principal brain metabolite.
Mechanism & Target Class
Mechanism & Target Class
A linear heptapeptide consisting of the ACTH(4-7) core sequence (Met-Glu-His-Phe) extended with a C-terminal Pro-Gly-Pro tripeptide. The Pro-Gly-Pro extension confers resistance to prolyl endopeptidase cleavage relative to the native ACTH(4-10) parent sequence, and the PGP fragment is the predominant brain metabolite identified in distribution studies. In-vitro work has characterized specific, calcium-dependent, reversible binding to a membrane site in rodent brain tissue, consistent with a G-protein-coupled receptor structural context. The methionine residue is oxidation-susceptible, and the histidine and N-terminal residues support copper(II) coordination chemistry studied in neuronal cell models.
Storage & Handling
Storage & Handling
Lyophilized
20°C, protected from light and moisture
stable long term.
The methionine residue is oxidation-susceptible; protect from light/air; avoid freeze-thaw.
References
References
Reviews
- 1
Dergunova LV, Filippenkov IB, Limborska SA, Myasoedov NF. (2021). Med Res Rev
- 2
Dergunova LV, et al. (2020). Biochemistry (Moscow)
Reviews
- 3
Levitskaya NG, et al. (2018). Biol Bull
- 4
Tsai SJ. (2007). Medical Hypotheses
Clinical
- 5
Gusev EI, et al. (2018). Zh Nevrol Psikhiatr
- 6
Lebedeva IS, et al. (2018). Bull Exp Biol Med
- 7
Kurysheva NI, et al. (2001). Zh Nevrol Psikhiatr
- 8
Polunin GS, et al. (2000). Vestn Oftalmol
- 9
Gusev EI, et al. (1997). Zh Nevrol Psikhiatr
Primary research
- 10
Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. (2022). ACS Chem Neurosci
- 11
Sudarkina OY, et al. (2021). Int J Mol Sci
- 12
Filippenkov IB, et al. (2020). Genes (Basel)
- 13
Dergunova LV, Filippenkov IB, et al. (2018). BMC Genomics
- 14
Medvedeva EV, Dmitrieva VG, et al. (2017). Mol Genet Genomics
- 15
Medvedeva EV, et al. (2014). BMC Genomics
- 16
Manchenko DM, et al. (2012). Neurosci Behav Physiol
- 17
Agniullin YaV, et al. (2009). J Mol Neurosci
- 18
Shadrina MI, et al. (2007). Neurosci Lett
- 19
Dolotov OV, et al. (2006). Brain Res
- 20
Dolotov OV, et al. (2006). J Neurochem
- 21
Shevchenko KV, et al. (2006). Russ J Bioorg Chem
- 22
Eremin KO, et al. (2005). Neurochem Res
- 23
Levitskaya NG, et al. (2004). Neurosci Behav Physiol
- 24
Kost NV, et al. (2001). Russ J Bioorg Chem
- 25
Bashkatova VG, et al. (2001). Brain Res
- 26
Adan RAH, et al. (1994). Eur J Pharmacol
Primary Database
Primary Database
Also known as: ACTH(4-7)-Pro-Gly-Pro
View this compound in the Research Library →- Jul 5, 2026Dorothy P.Verified
got the order fast, qr scan brought up the coa right away and everything...
got the order fast, qr scan brought up the coa right away and everything lined up with the lot on the vial, packaging was better than average, support was helpful when i asked about storage, solid all around
- Jun 14, 2026Kyle S.Verified
The supplier provides accessible verification of purity through a QR...
The supplier provides accessible verification of purity through a QR code on each vial that directs to the relevant third-party COA. Lot numbers on the physical product align with the documentation. Packaging is protective and professional. Shipping has been prompt on recent orders. Support handles specification inquiries efficiently. The overall process supports laboratory procurement needs.
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
