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Type
Synthetic peptide (acylated, 39 residues)
Molecular formula
C221H342N46O68
Molecular weight
~4,731 Da
CAS number
2381089-83-2
Amino acids
39
Fatty acid chain
C20 diacid
Modification
Aib at positions 2 and 20; α-methyl-Leu at position 13; C-terminal amide; Lys17-linked C20 fatty-diacid acylation via a γ-Glu/AEEA linker.
A C20-acylated 39-residue synthetic peptide. Cryo-EM studies of LUV RT bound to its class B GPCR–Gs complexes reveal a continuous α-helical conformation in which the N-terminal segment inserts into the receptor transmembrane bundle and the central segment contacts the extracellular loops. Non-standard residues (Aib, α-methyl-Leu) confer protease resistance; the C20 fatty-diacid side chain confers reversible albumin binding, extending circulatory half-life.
Lyophilized
20°C (-80°C long term)
powder typically stable ~24 months.
Aliquot to avoid freeze-thaw; protect from light; keep sealed and dry.
Reviews
Gutgesell RM, Nogueiras R, Tschöp MH, Müller TD. (2024). Diabetes Therapy
Misra S, et al. (2025). J Basic Clin Physiol Pharmacol
Reviews
Systematic review & meta-analysis (2025). PubMed
Pasqualotto E, et al. (2024). Metabolism Open
Doggrell SA. (2023). Expert Opin Investig Drugs
Kaur M, Misra S. (2024). Eur J Clin Pharmacol
Ray A. (2023). Expert Opin Investig Drugs
Tetelbaum L, Mullally JA, Frishman WH. (2024). Cardiol Rev
Sinha B, Ghosal S. (2025). Obesity (Silver Spring)
Clinical
Coskun T, et al. (2025). Lancet Diabetes & Endocrinology
Giblin K, et al. (2026). Diabetes, Obesity and Metabolism
Sanyal AJ, et al. (2024). Nature Medicine
Urva S, et al. (2023). Diabetes, Obesity and Metabolism
Primary research
Briand F, et al. (2025). Obesity
Marathe SJ, et al. (2025). npj Metabolic Health and Disease
Li W, et al. (2024). Cell Discovery
Regmi A, Roell W. (2023). STAR Protocols
Rosenstock J, et al. (2023). The Lancet
Jastreboff AM, et al. (2023). NEJM
Urva S, et al. (2022). The Lancet
Coskun T, et al. (2022). Cell Metabolism