Cerebrolysin

A porcine brain-derived preparation of low-molecular-weight peptides and free amino acids produced by standardized enzymatic proteolysis (heterogeneous hydrolysate, peptide fraction <10 kDa).

Molecular Profile

Type
Porcine brain-derived neuropeptide and amino-acid preparation (enzymatic hydrolysate; heterogeneous mixture)
Molecular formula
n/a — heterogeneous mixture
Molecular weight
Peptide fraction <10 kDa
CAS number
12656-61-0
Modification
Enzymatic proteolysis and standardized fractionation of purified porcine brain proteins; no synthetic chemical modification.

Mechanism & Target Class

A heterogeneous preparation of low-molecular-weight peptides and free amino acids derived by standardized enzymatic proteolysis of purified porcine brain proteins. The peptide fraction is below approximately 10 kDa. Independent mass-spectrometry profiling (HPLC-ESI ion-trap and UHPLC-ion-mobility-QTOF) identified the main peptide constituents as derived from structural proteins (tubulin, actin, myelin basic protein); intact endogenous neurotrophic-factor fragments were not detected in that analysis. As a peptide-containing hydrolysate, its constituents are subject to enzymatic degradation rather than being stable to oral exposure.

Storage & Handling

Lyophilized
Store per supplier specification; protect from light and moisture; lyophilized material typically stored at -20°C.
Handling
Peptide constituents are degraded in the gastrointestinal tract.

Primary Database

DrugBank DB16599 ↗

References (32)

  1. Reviews

    1

    Patel PN, Mangal D, Patel K. (2025). Cureus

    DOI: 10.7759/cureus.91054

  2. 2

    Ziganshina LE, Abakumova T, Nurkhametova D, Ivanchenko K. (2023). Cochrane Database of Systematic Reviews

    DOI: 10.1002/14651858.CD007026PubMed 37818733

  3. 3

    Rejdak K, Sienkiewicz-Jarosz H, Bienkowski P, Alvarez XA. (2023). Medicinal Research Reviews

    DOI: 10.1002/med.21960

  4. 4

    Ziganshina LE, Abakumova T, Vernay L. (2020). Cochrane Database of Systematic Reviews

    DOI: 10.1002/14651858.CD007026.pub6

  5. 5

    Cui S, Chen N, Yang M, Guo J, Zhou M, Zhu C, He L. (2019). Cochrane Database of Systematic Reviews

    DOI: 10.1002/14651858.CD008900.pub3PubMed 31710397

  6. 6

    Gauthier S, Proaño JV, Jia J, Froelich L, Vester JC, Doppler E. (2015). Dementia and Geriatric Cognitive Disorders

    PubMed 25832905

  7. 7

    Chen N, Yang M, Guo J, Zhou M, Zhu C, He L. (2013). Cochrane Database of Systematic Reviews

    DOI: 10.1002/14651858.CD008900.pub2PubMed 23440834

  8. Clinical

    8

    Naseer MA, Dahshan A, Rabah A, Fouad AM, et al. (2023). Journal of Endocrinology and Diabetes

    DOI: 10.15226/2374-6890/10/1/001159

  9. 9

    Vester JC, Buzoianu AD, Florian SI, et al. (2021). Neurological Sciences

    DOI: 10.1007/s10072-020-04974-6PubMed 33620612

  10. 10

    Muresanu DF, Florian S, Hömberg V, et al. (2020). Neurological Sciences

    DOI: 10.1007/s10072-019-04181-yNCT01606111

  11. 11

    Poon W, Matula C, Vos PE, Muresanu DF, et al. (2020). Neurological Sciences

    DOI: 10.1007/s10072-019-04149-yPubMed 31494820

  12. 12

    Ashrafi MR, Mohammadi M, Vafaee-Shahi M, Tavasoli AR, Badv RS, et al. (2019). Iranian Journal of Pediatrics

    DOI: 10.5812/ijp.80991

  13. 13

    Guekht A, Vester J, Heiss WD, Gusev E, Hoemberg V, Rahlfs VW, et al. (2017). Neurological Sciences

    DOI: 10.1007/s10072-017-3037-z

  14. 14

    Muresanu DF, Heiss WD, Hoemberg V, Bajenaru O, Popescu CD, Vester JC, et al. (2016). Stroke

    DOI: 10.1161/STROKEAHA.115.009416PubMed 26564102

  15. 15

    Lang W, Stadler CH, Poljakovic Z, Fleet D; Lyse Study Group. (2013). International Journal of Stroke

    DOI: 10.1111/j.1747-4949.2012.00901.xPubMed 23009193

  16. 16

    Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z; CASTA Investigators. (2012). Stroke

    DOI: 10.1161/STROKEAHA.111.628537PubMed 22282884

  17. 17

    Alvarez XA, Cacabelos R, Sampedro C, Couceiro V, Aleixandre M, Vargas M, et al. (2011). Current Alzheimer Research

    PubMed 21679156

  18. 18

    Hong Z, Moessler H, Bornstein N, Brainin M, Heiss WD; CASTA Investigators. (2009). International Journal of Stroke

    PubMed 19765131

  19. 19

    Alvarez XA, Cacabelos R, Laredo M, et al. (2006). European Journal of Neurology

    DOI: 10.1111/j.1468-1331.2006.01222.x

  20. 20

    Gorbachevskaya N, Bashina V, Gratchev V, Iznak A. (2001). Brain & Development

    DOI: 10.1016/S0387-7604(01)00349-7

  21. Primary research

    21

    Mishra et al. (2024). Cureus

    PubMed 38524067

  22. 22

    Yang B, Li Y, Guo W, Zhang Q, Pan L, Duan K, et al. (2023). Journal of Chromatography B

    DOI: 10.1016/j.jchromb.2023.123755PubMed 37220681

  23. 23

    Kang DH, Choi BY, Lee SH, Kho AR, Jeong JH, Hong DK, et al. (2020). Frontiers in Neuroscience

    DOI: 10.3389/fnins.2020.568813

  24. 24

    Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, et al. (2015). Journal of Experimental Neuroscience

    DOI: 10.4137/JEN.S25521

  25. 25

    Gevaert B, D'Hondt M, Bracke N, Yao H, Wynendaele E, Vissers JPC, et al. (2015). Drug Testing and Analysis

    DOI: 10.1002/dta.1817

  26. 26

    Guan X, Wang Y, Kai G, Zhao S, Huang T, Li Y, et al. (2019). Frontiers in Pharmacology

    DOI: 10.3389/fphar.2019.01245

  27. 27

    Dong Y, et al. (2016). Neural Regeneration Research

    PubMed 26981106

  28. 28

    Tincer G, et al. (2008). Journal of Neural Transmission

    PubMed 18600331

  29. 29

    Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. (2007). Acta Neuropathologica

    DOI: 10.1007/s00401-006-0166-5PubMed 17131129

  30. 30

    Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, et al. (2006). Journal of Neuroscience Research

    PubMed 16511867

  31. 31

    Hartbauer M, Hutter-Paier B, Skofitsch G, Windisch M. (2001). Journal of Neural Transmission

    DOI: 10.1007/s007020170067PubMed 11475013

  32. 32

    Rockenstein E, Adame A, Mante M, Moessler H, Windisch M, Masliah E. (2003). Journal of Neural Transmission

    DOI: 10.1007/s00702-003-0025-7