CJC-1295 with DAC vs CJC-1295 no DAC
CJC-1295 no DAC (also written CJC-1295 without DAC) and CJC-1295 with DAC carry the same tetrasubstituted GRF(1-29) sequence (D-Ala2, Gln8, Ala15, Leu27) ending in an amide.
CJC-1295 with DAC adds a lysine at position 30 carrying a maleimidopropionyl (DAC) group, which raises the molecular weight from ~3,368 g/mol for CJC-1295 No DAC to ~3,647 g/mol.
Structure side by side
| Property | CJC-1295 with DAC | CJC-1295 No DAC |
|---|---|---|
| Type | Synthetic peptide (tetrasubstituted GRF(1-29) sequence, 30 residues, with an albumin-binding DAC group) | Synthetic peptide (tetrasubstituted, 29 residues) |
| Residues | 30 | 29 |
| Sequence | H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-NH2 (Nε-3-maleimidopropionyl on the C-terminal Lys30) | H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Molecular weight | ~3,647 g/mol | ~3,368 g/mol |
| Molecular formula | C165H269N47O46 | C152H252N44O42 |
| Modification | Four substitutions relative to GRF(1-29) — D-Ala2, Gln8, Ala15, Leu27 — conferring resistance to dipeptidyl peptidase-4 and other plasma proteases; C-terminal amidation; and an Nε-3-maleimidopropionyl-Lys30 (DAC) linker whose maleimide forms a covalent thioether bond with cysteine-34 of serum albumin. | Tetrasubstituted GRF(1-29) (D-Ala2, Gln8, Ala15, Leu27); C-terminal amide. The substitutions are positioned to resist DPP-IV cleavage, asparagine deamidation, and methionine oxidation. Unlike the DAC variant, it lacks the C-terminal albumin-binding maleimidopropionyl group. |
| Storage, sealed powder | -20°C; protected from light and moisture; frozen for longer-term storage. | -20°C; lyophilized peptide stored desiccated and protected from light. |
| References | 21 cited in the record | 21 cited in the record |
The CAS number is not shown: both records list 863288-34-0, and two different compounds cannot share one.
Records and products
Questions
What is the structural difference between CJC-1295 with DAC and CJC-1295 No DAC?
CJC-1295 no DAC (also written CJC-1295 without DAC) and CJC-1295 with DAC carry the same tetrasubstituted GRF(1-29) sequence (D-Ala2, Gln8, Ala15, Leu27) ending in an amide. CJC-1295 with DAC adds a lysine at position 30 carrying a maleimidopropionyl (DAC) group, which raises the molecular weight from ~3,368 g/mol for CJC-1295 No DAC to ~3,647 g/mol.
How are CJC-1295 with DAC and CJC-1295 No DAC stored as sealed powder?
CJC-1295 with DAC: -20°C; protected from light and moisture; frozen for longer-term storage. CJC-1295 No DAC: -20°C; lyophilized peptide stored desiccated and protected from light.
How is the identity of CJC-1295 with DAC and CJC-1295 No DAC confirmed?
By mass spectrometry: the measured mass is compared with the expected molecular weight, ~3,647 g/mol for CJC-1295 with DAC and ~3,368 g/mol for CJC-1295 No DAC. Purity is measured separately by HPLC, and every lot we sell has its certificate at luvaminos.com/coa.
Other comparisons