Selank vs Semax
Selank and Semax are both synthetic 7-residue peptides that end in the same Pro-Gly-Pro motif.
Selank extends the tuftsin sequence (Thr-Lys-Pro-Arg) and Semax extends the ACTH(4-7) core (Met-Glu-His-Phe), so the two share only their last three residues.
Structure side by side
| Property | Selank | Semax |
|---|---|---|
| Type | Synthetic heptapeptide (tuftsin analog) | Synthetic peptide (heptapeptide) |
| Residues | 7 | 7 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) | Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) |
| Molecular weight | 751.88 g/mol | 813.93 g/mol |
| Molecular formula | C33H57N11O9 | C37H51N9O10S |
| CAS number | 129954-34-3 | 80714-61-0 |
| Modification | Free termini; tuftsin (Thr-Lys-Pro-Arg) extended with a C-terminal Pro-Gly-Pro motif to confer protease resistance. N-Acetyl Selank adds N-terminal acetylation as a further stability modification. | C-terminal Pro-Gly-Pro tripeptide extension of the ACTH(4-7) core; confers resistance to prolyl endopeptidase degradation; PGP is the principal brain metabolite. |
| Form we sell | Lyophilized powder | Lyophilized powder |
| Storage, sealed powder | -20°C, protected from light and moisture; stable long term. | -20°C, protected from light and moisture; stable long term. |
| References | 27 cited in the record | 26 cited in the record |
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Questions
What is the structural difference between Selank and Semax?
Selank and Semax are both synthetic 7-residue peptides that end in the same Pro-Gly-Pro motif. Selank extends the tuftsin sequence (Thr-Lys-Pro-Arg) and Semax extends the ACTH(4-7) core (Met-Glu-His-Phe), so the two share only their last three residues.
How are Selank and Semax stored as sealed powder?
Selank: -20°C, protected from light and moisture; stable long term. Semax: -20°C, protected from light and moisture; stable long term.
How is the identity of Selank and Semax confirmed?
By mass spectrometry: the measured mass is compared with the expected molecular weight, 751.88 g/mol for Selank and 813.93 g/mol for Semax. Purity is measured separately by HPLC, and every lot we sell has its certificate at luvaminos.com/coa.
Other comparisons