Luvaminos

DSIP

An amphiphilic synthetic nonapeptide with no identified gene precursor or cloned receptor.

Quick answers

What is DSIP?

DSIP is an amphiphilic synthetic nonapeptide with no identified gene precursor or cloned receptor. It is a synthetic peptide (nonapeptide) of 9 amino acids with a molecular weight of 848.8 g/mol and the formula C35H48N10O15.

How much published research cites DSIP?

The Luvaminos DSIP record cites 22 published references, dated 1977 to 2009. Each is listed on this page with a link to its source.

Does Luvaminos test DSIP, and where is the certificate?

Luvaminos does not currently stock DSIP. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

How is DSIP powder stored?

Sealed DSIP powder: -20 °C; protect from light and moisture; stable up to 1 year. Sensitive to aminopeptidase cleavage; alpha-Asp/beta-Asp isomerization is relevant to identity; protect from light.

Molecular Profile

Type
Synthetic peptide (nonapeptide)
Molecular formula
C35H48N10O15
Molecular weight
848.8 g/mol
CAS number
62568-57-4
Amino acids
9
Sequence
WAGGDASGE
Modification
None (native peptide)

Mechanism & Target Class

An amphiphilic nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, ~850 Da) whose gene precursor has not been identified and for which no dedicated receptor has been cloned. It has no close sequence homologues and co-localizes immunohistochemically with other small peptides in structural distribution-mapping studies. The unmodified backbone is subject to rapid degradation by aminopeptidases, giving a short in-vitro half-life that is relevant to handling and assay design; alpha-Asp/beta-Asp isomerization at the Asp residues is a recognized identity consideration.

Storage & Handling

Lyophilized
-20 °C; protect from light and moisture; stable up to 1 year.
Handling
Sensitive to aminopeptidase cleavage; alpha-Asp/beta-Asp isomerization is relevant to identity; protect from light.

Primary Database

PubChem CID 68816 ↗

References (22)

  1. Reviews

    1

    Gimble JM, et al. (2009). Obes. Rev.

    DOI: 10.1111/j.1467-789X.2009.00661.x

  2. 2

    Kovalzon VM, Strekalova TV (2006). J. Neurochem.

    DOI: 10.1111/j.1471-4159.2006.03693.x

  3. 3

    Graf MV, Kastin AJ (1986). Peptides

    DOI: 10.1016/0196-9781(86)90148-8PubMed 3550726

  4. Clinical

    4

    Westrin A, Ekman R, Träskman-Bendz L (1998). Biol. Psychiatry

    DOI: 10.1016/S0006-3223(97)00254-0PubMed 9606527

  5. 5

    Bes F, Hofman W, Schuur J, van Boxtel C (1992). Neuropsychobiology

    DOI: 10.1159/000118919PubMed 1299794

  6. 6

    Schneider-Helmert D (1986). Eur. Neurol.

    DOI: 10.1159/000116050PubMed 3792404

  7. 7

    Schneider-Helmert D, Schoenenberger GA (1981). Experientia

    DOI: 10.1007/BF01971753PubMed 7028502

  8. 8

    Dick P, Grandjean ME, Tissot R (1983). Neuropsychobiology

    DOI: 10.1159/000118012PubMed 6328354

  9. 9

    Dick P, et al. (1984). Eur. Neurol.

    DOI: 10.1159/000115715PubMed 6548969

  10. 10

    Lindström LH, Ekman R, Walleus H, Widerlöv E (1985). Prog. Neuropsychopharmacol. Biol. Psychiatry

    DOI: 10.1016/0278-5846(85)90182-4PubMed 2859636

  11. 11

    Ernst A, et al. (1987). J. Neurol.

    DOI: 10.1007/BF00314191PubMed 2448424

  12. Primary research

    12

    Sudakova KV, et al. (2004). Pathophysiology

    DOI: 10.1016/j.pathophys.2004.03.003PubMed 15364118

  13. 13

    Charnay Y, et al. (1989). Neuroendocrinology

    DOI: 10.1159/000125110PubMed 2657475

  14. 14

    Iyer KS, et al. (1988). Proc. Natl. Acad. Sci. USA

    DOI: 10.1073/pnas.85.10.3653

  15. 15

    Graf MV, Schoenenberger GA (1987). J. Neurochem.

    DOI: 10.1111/j.1471-4159.1987.tb05654.xPubMed 3029331

  16. 16

    Graf MV, Kastin AJ, Coy DH, Fischman AJ (1985). Neuroendocrinology

    DOI: 10.1159/000124200PubMed 2995861

  17. 17

    Graf MV, et al. (1984). J. Clin. Endocrinol. Metab.

    DOI: 10.1210/jcem-59-1-127PubMed 6547144

  18. 18

    Monnier M, et al. (1977). Experientia

    DOI: 10.1007/BF01922266

  19. 19

    Schoenenberger GA, Monnier M (1977). Proc Natl Acad Sci USA

    DOI: 10.1073/pnas.74.3.1282

  20. 20

    Marks N, Stern F, Kastin AJ, Coy DH (1977). Brain Res Bull

    DOI: 10.1016/0361-9230(77)90058-2PubMed 606344

  21. 21

    Khvatova EM, Rubanova NA, Prudchenko IA, Mikhaleva II (1995). FEBS Lett.

    DOI: 10.1016/0014-5793(95)00661-rPubMed 7628639

  22. 22

    Shustanova TA, et al. (2001). Biochemistry (Mosc)

    DOI: 10.1023/A:1010255230338PubMed 11421812

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About DSIP

What is DSIP?

DSIP is an amphiphilic synthetic nonapeptide with no identified gene precursor or cloned receptor.

What are the molecular formula, molecular weight and CAS number of DSIP?

DSIP: molecular formula C35H48N10O15, molecular weight 848.8 g/mol and CAS number 62568-57-4.

What is the sequence of DSIP?

WAGGDASGE.

How is DSIP powder stored?

-20 °C; protect from light and moisture; stable up to 1 year.