LUV-31
A synthetic aromatic-cationic tetrapeptide studied as a research tool for its selective interaction with cardiolipin on the inner mitochondrial membrane.
View LUV-31 in the storeQuick answers
What is LUV-31?
LUV-31 is a synthetic aromatic-cationic tetrapeptide studied as a research tool for its selective interaction with cardiolipin on the inner mitochondrial membrane. It is a synthetic aromatic-cationic tetrapeptide (C-terminally amidated, mitochondria-targeted) of 4 amino acids.
Does Luvaminos test LUV-31, and where is the certificate?
Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial. No LUV-31 lot has a published certificate right now.
How is LUV-31 powder stored?
Sealed LUV-31 powder: 2–8 °C routine handling; −20 °C or below long-term; protect from light. Lyophilized material reported stable up to 24 months at recommended conditions. The N-terminal D-arginine and 2',6'-dimethyltyrosine modifications confer resistance to enzymatic degradation relative to all-L peptides. brief room-temperature exposure during transport is generally tolerated.
How is LUV-31 different from MOTS-c?
LUV-31 and MOTS-c are different compounds: LUV-31 has 4 amino acids; MOTS-c has 16 amino acids, a molecular weight of ~2,175 g/mol and formula C101H152N28O22S2.
Molecular Profile
- Type
- Synthetic aromatic-cationic tetrapeptide (C-terminally amidated, mitochondria-targeted)
- Amino acids
- 4
Mechanism & Target Class
LUV-31 is a water-soluble aromatic-cationic tetrapeptide characterized by an alternating motif of cationic (D-Arg, Lys) and aromatic (2',6'-dimethyltyrosine, Phe) side chains that confers a net positive charge while maintaining membrane permeability. In published research it is characterized as concentrating selectively in the inner mitochondrial membrane through electrostatic and hydrophobic interactions, where it associates with the anionic phospholipid cardiolipin. Mechanistic work describes binding at the membrane interfacial region and modulation of membrane surface electrostatics, lipid packing, and the cardiolipin–cytochrome c interaction. Its target class is a membrane phospholipid (cardiolipin) and associated cardiolipin-binding proteins of the oxidative-phosphorylation and 2-oxoglutarate-metabolism machinery — it is not described as a cell-surface receptor ligand.
Storage & Handling
- Lyophilized
- 2–8 °C routine handling; −20 °C or below long-term; protect from light. Lyophilized material reported stable up to 24 months at recommended conditions.
- Handling
- The N-terminal D-arginine and 2',6'-dimethyltyrosine modifications confer resistance to enzymatic degradation relative to all-L peptides. Water-soluble; brief room-temperature exposure during transport is generally tolerated.
Primary Database
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