Thymalin

A thymus-derived polypeptide complex studied in research models of immune-cell signaling, thymic function, and biogerontology.

Updated August 20, 2026

Quick answers

What is Thymalin?

Thymalin is a thymic peptide preparation (polypeptide complex).

How much published research cites Thymalin?

The Luvaminos Thymalin record cites 23 published references, dated 1993 to 2023. Each is listed on this page with a link to its source.

Does Luvaminos test Thymalin, and where is the certificate?

Luvaminos does not currently stock Thymalin. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

How is Thymalin powder stored?

Sealed Thymalin powder: Store cool and dry as a lyophilized powder; protect from heat, light, and moisture. Polypeptide complex rather than a single defined peptide.

How is Thymalin different from Thymosin Alpha-1?

Thymalin and Thymosin Alpha-1 are different compounds: Thymalin is a thymic peptide preparation (polypeptide complex); Thymosin Alpha-1 has 28 amino acids, a molecular weight of ~3,108.3 Da and formula C129H215N33O55. Thymosin Alpha-1: N-terminal acetylation at Ser1.

Molecular Profile

Type: Thymic peptide preparation (polypeptide complex)

Mechanism & Target Class

A complex of low-molecular-weight polypeptides extracted from thymus tissue, studied in the bioregulator literature as a thymic immunomodulatory preparation. Research characterizes the preparation as acting on lymphoid and myeloid cell populations, with reported effects on thymocyte blastogenesis, differentiation, proliferation, and apoptosis. Mechanistic work has examined intracellular signal transduction, including signaling along the sphingomyelin pathway in thymocytes (Khavinson et al., 2002), and has framed the preparation's activity within a broader peptide-bioregulator model in which short thymic peptides modulate tissue-specific cell differentiation across age. Investigators have associated defining short-peptide dipeptide motifs (reported in the preparation context as KE and EW dipeptides) with gene-expression and protein-synthesis readouts in research models (Linkova et al., 2023). Because Thymalin is a polypeptide complex rather than a single defined molecule, no single high-affinity receptor, molecular formula, or molecular weight is established for the preparation across the literature.

Storage & Handling

Lyophilized: Store cool and dry as a lyophilized powder; protect from heat, light, and moisture.
Handling: Polypeptide complex rather than a single defined peptide.

References (23)

Reviews
1
Khavinson VKh, Morozov VG. (2003). Neuro Endocrinology Letters
PubMed 14523363
2
Khavinson VKh, Morozov VG. (2002). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 12577695
3
Khavinson VKh. (2002). Neuro Endocrinology Letters
PubMed 12374906
4
Khavinson VK. (2001). Bulletin of Experimental Biology and Medicine
DOI: 10.1023/a:1013058701974 PubMed 11713572
5
Morozov VG, Khavinson VK. (1997). International Journal of Immunopharmacology
DOI: 10.1016/s0192-0561(97)00058-1 PubMed 9637345
Clinical
6
Kuznik BI, Shapovalov KG, Smolyakov YN, Lukyanov SA, Tereshkov PP, Kazantseva LS. (2022). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 36169363
7
Khavinson VK, Kuznik BI, Trofimova SV, Volchkov VA, Rukavishnikova SA, Titova ON. (2021). Stem Cell Reviews and Reports
DOI: 10.1007/s12015-020-10087-6 PubMed 33575961
8
Litvinenko GI, Shurlygina AV, Dergacheva TI, Mel'nikova EV, Trufakin VA. (2015). Bulletin of Experimental Biology and Medicine
DOI: 10.1007/s10517-015-2890-0 PubMed 26033592
9
Tsybikov MN, Likhanov ID, Borshchevskii VS, Kuznik BI, Tsepelev VL, Maslo EYu. (2012). Khirurgiia (Surgery)
PubMed 23258355
Primary research
10
Linkova N, Khavinson V, Diatlova A, Petukhov M, Vladimirova E, Sukhareva M. (2023). International Journal of Molecular Sciences
DOI: 10.3390/ijms241713377 PubMed 37686182
11
Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, et al. (2022). International Journal of Molecular Sciences
DOI: 10.3390/ijms23073607 PubMed 35408963
12
Khavinson VK, Linkova NS, Kvetnoy IM, Polyakova VO, Drobintseva AO, Kvetnaia TV. (2020). Bulletin of Experimental Biology and Medicine
DOI: 10.1007/s10517-020-05016-z PubMed 33237528
13
Zhukova GV, Schikhlyarova AI, Barteneva TA, Shevchenko AN, Zakharyuta FM. (2018). Bulletin of Experimental Biology and Medicine
DOI: 10.1007/s10517-018-4104-z PubMed 29797130
14
Ryzhak AP, Chalisova NI, Lin'kova NS, Khalimov RI, Ryzhak GA, Zhekalov AN. (2015). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 26390619
15
Kuznetsova TA, Besednova NN, Zaporozhets TS, Smolina TP, Kazha AK, Ivanushko LA. (2013). Antibiotics and Chemotherapy (Antibiotiki i Khimioterapiia)
PubMed 24734422
16
Sevostianova NN, Linkova NS, Polyakova VO, Chervyakova NA, Kostylev AV, Durnova AO. (2013). Bulletin of Experimental Biology and Medicine
DOI: 10.1007/s10517-013-2000-0 PubMed 23486604
17
Lin'kova NS, Polyakova VO, Trofimov AV, Kvetnoy IM, Khavinson VKh. (2011). Bulletin of Experimental Biology and Medicine
DOI: 10.1007/s10517-011-1298-8 PubMed 22238759
18
Labunets IF, Rodnichenko AE, Magdich LV, Butenko GM. (2011). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 21957575
19
Labunets' IF. (2007). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 17969591
20
Khlystova ZS, Kalinina II, Shmeleva SP. (2003). Bulletin of Experimental Biology and Medicine
DOI: 10.1023/a:1025449923475 PubMed 12937685
21
Khavinson VKh, Malinin VV, Chalisova NI, Grigor'ev EI. (2002). Advances in Gerontology (Uspekhi Gerontologii)
PubMed 12096446
22
Khavinson VKh, Rybakina EG, Malinin VV, Pivanovich IY, Shanin SN, Korneva EA. (2002). Bulletin of Experimental Biology and Medicine
DOI: 10.1023/a:1019830308824 PubMed 12420072
23
Khavinson VKh, Kozhemiakin AL, Volgarev AP, Platonov VG. (1993). Journal of Microbiology, Epidemiology and Immunobiology
PubMed 8067076

Related compounds

Researcher Verification