LUV SM

A 31-residue C18-acylated synthetic peptide analogue characterized by cryo-EM in complex with a class B GPCR.

Molecular Profile

Type
Synthetic peptide (acylated, 31 residues)
Molecular formula
C187H291N45O59
Molecular weight
~4,114 g/mol
CAS number
910463-68-2
Amino acids
31
Fatty acid chain
C18 diacid
Modification
Aib8 and Arg34 substitutions; Lys26 C18 fatty-diacid acylation via gamma-Glu and two AEEA linkers.

Mechanism & Target Class

A 31-residue synthetic peptide incorporating Aib at position 8 and Arg at position 34, with the Lys26 side chain acylated to a C18 fatty diacid via a γ-Glu/AEEA spacer. The Aib8 substitution confers resistance to enzymatic cleavage; the C18-diacid side chain provides reversible albumin binding that extends serum half-life. It has been characterized binding the extracellular domain and transmembrane pocket of a class B G protein–coupled receptor by cryo-EM.

Storage & Handling

Lyophilized
-20°C (-80°C long term); powder typically stable ~24 months.
Handling
Avoid freeze-thaw; protect from light; keep sealed and dry. Self-associates in aqueous solution.

Primary Database

PubChem CID 56843331 ↗

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