AOD-9604
A synthetic 16-residue cyclic peptide corresponding to the C-terminal domain of human growth hormone, characterized by NMR conformational analysis and bioanalytical structure studies.
Quick answers
What is AOD-9604?
AOD-9604 is a synthetic 16-residue cyclic peptide corresponding to the C-terminal domain of human growth hormone, characterized by NMR conformational analysis and bioanalytical structure studies. It is a synthetic peptide (cyclic, 16 residues) with a molecular weight of ~1,815 g/mol and the formula C78H123N23O23S2.
How much published research cites AOD-9604?
The Luvaminos AOD-9604 record cites 21 published references, dated 1978 to 2026. Each is listed on this page with a link to its source.
Does Luvaminos test AOD-9604, and where is the certificate?
Luvaminos does not currently stock AOD-9604. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.
What modifications does AOD-9604 carry?
AOD-9604: N-terminal tyrosine extension of the hGH 177–191 sequence; intramolecular Cys7–Cys14 disulfide bond forming a cyclic loop.
How is AOD-9604 powder stored?
Sealed AOD-9604 powder: -20 °C or colder, protected from light and moisture; stable for extended periods when kept frozen and sealed. Avoid repeated freeze–thaw cycles; protect from light and moisture; the disulfide is oxidation-sensitive — avoid reducing agents. The N-terminal tyrosine modification was introduced to improve stability relative to the unmodified C-terminal fragment.
How is AOD-9604 different from HGH Fragment 176-191?
AOD-9604 and HGH Fragment 176-191 are different compounds: AOD-9604 has 16 amino acids, a molecular weight of ~1,815 g/mol and formula C78H123N23O23S2; HGH Fragment 176-191 has 16 amino acids, a molecular weight of ~1,817 g/mol and formula C78H123N23O22S2. AOD-9604: N-terminal tyrosine extension of the hGH 177–191 sequence.
Molecular Profile
- Type
- Synthetic peptide (cyclic, 16 residues)
- Molecular formula
- C78H123N23O23S2
- Molecular weight
- ~1,815 g/mol
- CAS number
- 221231-10-3
- Amino acids
- 16
- Sequence
- YLRIVQCRSVEGSCGF
- Modification
- N-terminal tyrosine extension of the hGH 177–191 sequence; intramolecular Cys7–Cys14 disulfide bond forming a cyclic loop.
Mechanism & Target Class
A disulfide-cyclized 16-residue peptide corresponding to the C-terminal domain of human growth hormone (residues 177–191 plus an N-terminal tyrosine). The N-terminal tyrosine extension and the intramolecular Cys7–Cys14 disulfide bond constrain the backbone into a cyclic loop; NMR conformational analysis of the solution structure identifies type I β-turns in this region. The cyclic loop is distinct from the N-terminal region of the full-length protein, and the tyrosine modification was introduced to improve stability relative to the unmodified C-terminal fragment.
Storage & Handling
- Lyophilized
- -20 °C or colder, protected from light and moisture; stable for extended periods when kept frozen and sealed.
- Handling
- Avoid repeated freeze–thaw cycles; protect from light and moisture; the disulfide is oxidation-sensitive — avoid reducing agents. The N-terminal tyrosine modification was introduced to improve stability relative to the unmodified C-terminal fragment.
Primary Database
References (21)
Reviews
1Mendias CL, Awan TM. (2026). Sports Medicine
- 2
Kopchick JJ, et al. (2020). Nat Rev Endocrinol
- 3
Moré MI, Kenley D. (2014). Journal of Endocrinology and Metabolism
- 4
Stier H, Vos E, Kenley D. (2013). Journal of Endocrinology and Metabolism
- 5
Liao HJ, et al. (2024). Cartilage
- 6
Vijayakumar A, et al. (2010). Growth Horm IGF Res
Primary research
7Cox HD, et al. (2015). Drug Test Anal
- 8
Kwon DR, Park GY. (2015). Ann Clin Lab Sci
- 9
Vanhee C, et al. (2014). Drug Test Anal
- 10
Orlovius AK, et al. (2013). Drug Test Anal
- 11
Heffernan M, et al. (2001). Endocrinology
- 12
Heffernan MA, et al. (2001). Int J Obes
- 13
Heffernan MA, et al. (2000). Am J Physiol Endocrinol Metab
- 14
Ng FM, et al. (2000). Horm Res
- 15
Ng FM, et al. (2000). J Mol Endocrinol
- 16
Ogru E, et al. (2000). J Pept Res
- 17
Wijaya E, Ng FM. (1993). Biochem Mol Biol Int
- 18
Wu Z, Ng FM. (1993). Biochem Mol Biol Int
- 19
Ng FM, Bornstein J. (1978). American Journal of Physiology
- 20
Zhao L, Jiang H. (2023). Front Endocrinol
- 21
Høyer KL, et al. (2020). Physiol Rep
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