Luvaminos

SLU-PP-332

A synthetic small-molecule acylhydrazone studied as a chemical probe in nuclear-receptor and mitochondrial-metabolism research.

Quick answers

What is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule acylhydrazone studied as a chemical probe in nuclear-receptor and mitochondrial-metabolism research. It is a synthetic small molecule (acylhydrazone / benzohydrazide chemotype) with a molecular weight of 290.3 g/mol and the formula C18H14N2O2.

How much published research cites SLU-PP-332?

The Luvaminos SLU-PP-332 record cites 21 published references, dated 2002 to 2026. Each is listed on this page with a link to its source.

Does Luvaminos test SLU-PP-332, and where is the certificate?

Luvaminos does not currently stock SLU-PP-332. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

How is SLU-PP-332 powder stored?

Sealed SLU-PP-332 powder: Solid form is commonly stored desiccated and protected from light; vendor practice frequently specifies −20 °C for long-term stability. Protect from light, moisture, and heat. Consult the specific certificate of analysis for any given lot.

Molecular Profile

Type
Synthetic small molecule (acylhydrazone / benzohydrazide chemotype)
Molecular formula
C18H14N2O2
Molecular weight
290.3 g/mol
CAS number
303760-60-3

Mechanism & Target Class

SLU-PP-332 is a synthetic small molecule (acylhydrazone chemotype) that binds within the ligand-binding domain of the estrogen-related receptors (ERRα, ERRβ, ERRγ), a subfamily of orphan nuclear receptors within the nuclear-receptor superfamily. Despite the name, ERRs do not bind estrogen; they are constitutively active transcription factors that associate with PGC-1α/β coactivators. SLU-PP-332 was engineered from GSK4716 by medicinal-chemistry modification, and structural studies describe how it binds within the ERR ligand-binding domain and stabilizes the receptor conformation that recruits the PGC-1 coactivator.

Storage & Handling

Lyophilized
Solid form is commonly stored desiccated and protected from light; vendor practice frequently specifies −20 °C for long-term stability.
Handling
Protect from light, moisture, and heat. Consult the specific certificate of analysis for any given lot.

Primary Database

PubChem CID 5338394 ↗

References (21)

  1. Reviews

    1

    Sopariwala DH, Nguyen H, Narkar VA (2023). International Journal of Sports Medicine

    DOI: 10.1055/a-2035-8192PubMed 36787804

  2. 2

    Fan W, Atkins AR, Yu RT, Downes M, Evans RM (2013). Journal of Molecular Endocrinology

    PubMed 24280961

  3. 3

    Giguère V (2008). Endocr Rev

    DOI: 10.1210/er.2008-0017PubMed 18664618

  4. 4

    Giguère V (2002). Trends Endocrinol Metab

    DOI: 10.1016/s1043-2760(02)00592-1PubMed 12185669

  5. Clinical

    5

    Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U (2025). Frontiers in Physiology

    DOI: 10.3389/fphys.2025.1616693PubMed 40692696

  6. Primary research

    6

    Avliyakulov NK, Sobolevsky T, Ahrens E (2026). Drug Testing and Analysis

    DOI: 10.1002/dta.70035PubMed 41688415

  7. 7

    Möller T, Krug O, Thevis M (2026). Rapid Communications in Mass Spectrometry

    DOI: 10.1002/rcm.70039

  8. 8

    Okda HE, Zhao P, Hayes M, Duvall C, Quillin E, Fang H, Mohammed BM, Hegazy L, Burris TP, Elgendy B (2026). International Journal of Biological Macromolecules

    DOI: 10.1016/j.ijbiomac.2026.151450PubMed 41850449

  9. 9

    Billon C, Appourchaux K, Côté I, Burris TP (2025). Journal of Pharmacology and Experimental Therapeutics

    DOI: 10.1016/j.jpet.2025.103787PubMed 41421047

  10. 10

    Fan W, Oh TG, Wang HJ, et al. (2025). Proceedings of the National Academy of Sciences USA

    DOI: 10.1073/pnas.2426179122

  11. 11

    Losby M, Hayes M, Valfort A, Walker J, Xu W, Zhang L, Billon C, Burris TP (2024). Molecular Pharmacology

    DOI: 10.1124/molpharm.124.000917PubMed 39168657

  12. 12

    Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP (2024). Journal of Pharmacology and Experimental Therapeutics

    DOI: 10.1124/jpet.123.001733PubMed 37739806

  13. 13

    Xu W, Billon C, Li H, et al. (2024). Circulation

    DOI: 10.1161/CIRCULATIONAHA.123.066542PubMed 37961903

  14. 14

    Wang XX, Myakala K, Libby AB, et al. (2023). The American Journal of Pathology

    DOI: 10.1016/j.ajpath.2023.07.008PubMed 37717940

  15. 15

    Hampton CS, Sitaula S, Billon C, et al. (2023). European Journal of Medicinal Chemistry

    DOI: 10.1016/j.ejmech.2023.115582PubMed 37421886

  16. 16

    Billon C, Sitaula S, Banerjee S, et al. (2023). ACS Chemical Biology

    DOI: 10.1021/acschembio.2c00720PubMed 36988910

  17. 17

    Wattez JS, Eury E, Hazen BC, et al. (2023). Molecular Metabolism

    DOI: 10.1016/j.molmet.2023.101670PubMed 36642217

  18. 18

    Shahien M, Elagawany M, Sitaula S, et al. (2020). Bioorganic Chemistry

    DOI: 10.1016/j.bioorg.2020.104079PubMed 32683181

  19. 19

    Huss JM, Imahashi K, Dufour CR, et al. (2007). Cell Metab

    DOI: 10.1016/j.cmet.2007.06.005PubMed 17618854

  20. 20

    Huss JM, Torra IP, Staels B, Giguère V, Kelly DP (2004). Mol Cell Biol

    DOI: 10.1128/MCB.24.20.9079-9091.2004PubMed 15456881

  21. 21

    Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP (2005). Mol Cell Biol

    DOI: 10.1128/MCB.25.24.10684-10694.2005PubMed 16314495

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About SLU-PP-332

What is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule acylhydrazone studied as a chemical probe in nuclear-receptor and mitochondrial-metabolism research.

What are the molecular formula, molecular weight and CAS number of SLU-PP-332?

SLU-PP-332: molecular formula C18H14N2O2, molecular weight 290.3 g/mol and CAS number 303760-60-3.

How is SLU-PP-332 powder stored?

Solid form is commonly stored desiccated and protected from light; vendor practice frequently specifies −20 °C for long-term stability.