SLU-PP-332

A synthetic small-molecule acylhydrazone studied as a chemical probe in nuclear-receptor and mitochondrial-metabolism research.

Molecular Profile

Type
Synthetic small molecule (acylhydrazone / benzohydrazide chemotype)
Molecular formula
C18H14N2O2
Molecular weight
290.3 g/mol
CAS number
303760-60-3

Mechanism & Target Class

SLU-PP-332 is a synthetic small molecule (acylhydrazone chemotype) that binds within the ligand-binding domain of the estrogen-related receptors (ERRα, ERRβ, ERRγ), a subfamily of orphan nuclear receptors within the nuclear-receptor superfamily. Despite the name, ERRs do not bind estrogen; they are constitutively active transcription factors that associate with PGC-1α/β coactivators. SLU-PP-332 was engineered from GSK4716 by medicinal-chemistry modification, and structural studies describe how it binds within the ERR ligand-binding domain and stabilizes the receptor conformation that recruits the PGC-1 coactivator.

Storage & Handling

Lyophilized
Solid form is commonly stored desiccated and protected from light; vendor practice frequently specifies −20 °C for long-term stability.
Handling
Protect from light, moisture, and heat. Discard solutions showing discoloration or precipitation. Consult the specific certificate of analysis for any given lot.

Primary Database

PubChem CID 5338394 ↗

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