MOTS-c / 5-Amino-1MQ

A combined metabolic-research preparation pairing a mitochondrial-derived peptide with a small-molecule NNMT inhibitor.

Molecular Profile

Type
Peptide / small-molecule blend

Components

MOTS-c

Molecular formula
C101H152N28O22S2
Molecular weight
~2,175 g/mol
CAS number
1627580-64-6
Sequence
MRWQEMGYIFYPRKLR

5-Amino-1MQ

Molecular formula
C10H11IN2
Molecular weight
286.11 g/mol
CAS number
42464-96-0

Mechanism & Target Class

Combines a mitochondrial-derived peptide (MOTS-c) with a small-molecule enzyme inhibitor (5-Amino-1MQ) that act on separate metabolic pathways; no single target applies. MOTS-c is a short cationic peptide encoded by an open reading frame within mitochondrial 12S rRNA (MT-RNR1 locus); mechanistic studies link it to inhibition of the folate-methionine one-carbon cycle, AICAR accumulation, and AMP-activated protein kinase (AMPK) activation, with stress-responsive nuclear translocation. 5-Amino-1MQ is a substrate-site small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT; EC 2.1.1.1), the cytosolic enzyme that transfers a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, yielding 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine; the cationic quinolinium ring occupies the nicotinamide substrate-binding pocket.

Storage & Handling

Lyophilized
-20°C; components typically stable ~24 months desiccated and protected from light.
Handling
Avoid freeze-thaw; aliquot; protect from light and moisture. The peptide component carries oxidation-sensitive methionine residues; the small-molecule salt is hygroscopic — keep desiccated.

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