Kisspeptin-10 – 10 mg

Form

Lyophilized powder

Size

10 mg per vial

Type

Linear decapeptide (C-terminally amidated), RF-amide peptide family

Formula

C₆₃H₈₃N₁₇O₁₄

Molecular weight

1302.4 g/mol

CAS number

374675-21-5

Amino acids

10

Purity test

HPLC

Identity test

Mass spectrometry

Laboratory

Freedom Diagnostics

Kisspeptin-10 is a linear decapeptide corresponding to the conserved C-terminal segment shared by the four naturally occurring kisspeptins (KP-54, KP-14, KP-13, KP-10), all of which terminate in an arginine-phenylalanine-amide (RF-amide) motif. C-terminal amidation is the single most critical structural determinant of the molecule's binding conformation, and structure-activity studies establish that the terminal amide is required for high-affinity engagement. Cryo-EM studies of KP-10 bound to its class A G-protein-coupled receptor complex define a three-segment binding mode in which the N-terminal residues (Tyr-Asn-Trp-Asn-Ser-Phe) sit between the receptor extracellular loops and the C-terminal RF-amide inserts into the transmembrane core (PDB 8ZJD), with Phe6, Arg9, and Phe10 identified as residues central to the interaction. KP-10 belongs to the RF-amide peptide family, alongside neuropeptide FF, prolactin-releasing peptide, and QRFP.