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For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Mitochondrial-derived peptide (16 residues)
Molecular formula
C101H152N28O22S2
Molecular weight
~2,175 g/mol
CAS number
1627580-64-6
Amino acids
16
Sequence
MRWQEMGYIFYPRKLR
Modification
Unmodified (free base); synthetic preparations are typically supplied as trifluoroacetate or acetate salt. Encoded within the mitochondrial 12S rRNA (MT-RNR1 locus).
Mechanism & Target Class
Mechanism & Target Class
A short cationic peptide encoded by an open reading frame within mitochondrial 12S rRNA (MT-RNR1 locus). Mechanistic studies identify two principal pathways: inhibition of the folate-methionine one-carbon cycle, which leads to AICAR accumulation and AMPK activation; and, under metabolic stress, AMPK-dependent translocation to the nucleus where the peptide associates with antioxidant-response elements and the NRF2/ATF-family transcription factors. Kim SJ et al. (2024) identified the CK2α subunit as a direct binding target in skeletal muscle, with the K14Q polymorphic variant showing altered binding relative to wild-type.
Storage & Handling
Storage & Handling
Lyophilized
20°C
powder typically stable ~24 months.
Avoid freeze-thaw; protect from light and moisture; methionine residues are oxidation-sensitive.
References
References
Reviews
- 1
Wan W, et al. (2023). J Transl Med
- 2
Zheng Y, et al. (2023). Front Endocrinol
Reviews
- 3
Yang B, et al. (2023). Front Physiol
- 4
Mohtashami Z, et al. (2022). Int J Mol Sci
- 5
Miller B, et al. (2022). J Clin Invest
- 6
Yoon TK, et al. (2022). Diabetes Metab J
- 7
Kim SJ, et al. (2021). GeroScience
- 8
Wu Y, et al. (2021). Front Endocrinol
- 9
Popov LD. (2019). Cell Tissue Res
- 10
Lee C, et al. (2016). Free Radic Biol Med
- 11
Fuku N, et al. (2015). Aging Cell
Clinical
- 12
Circulating-MDP COPD study group. (2023). Front Med
- 13
Pediatric MOTS-c study group. (2023). Diabetes Metab Syndr Obes
- 14
Reynolds JC, et al. (2021). Sci Rep
- 15
Hudson Biotech.. ClinicalTrials.gov
- 16
CohBar Inc.. ClinicalTrials.gov
- 17
Qin Q, et al. (2018). Int J Cardiol
Primary research
- 18
Kong BS, et al. (2025). Exp Mol Med
- 19
Kim SJ, et al. (2024). iScience
- 20
Yang L, et al. (2024). Acta Biochim Biophys Sin
- 21
Lu H, et al. (2024). Cell Rep
- 22
Zhong P, et al. (2022). J Cell Mol Med
- 23
Kumagai H, et al. (2022). Biochim Biophys Acta Gen Subj
- 24
Zempo H, et al. (2021). Aging (Albany NY)
- 25
Kumagai H, et al. (2021). Am J Physiol Endocrinol Metab
- 26
Reynolds JC, et al. (2021). Nat Commun
- 27
Yang B, et al. (2021). Biochim Biophys Acta Mol Basis Dis
- 28
Yin X, et al. (2020). Eur J Pharmacol
- 29
D'Souza RF, et al. (2020). Aging (Albany NY)
- 30
Lu H, et al. (2019). J Mol Med
- 31
Lu H, et al. (2019). Int J Mol Sci
- 32
Yan Z, et al. (2019). Pharmacol Res
- 33
Du C, et al. (2018). Pediatr Diabetes
- 34
MOTS-c BMSC differentiation study. (2018). Eur Rev Med Pharmacol Sci
- 35
Kim KH, et al. (2018). Cell Metabolism
- 36
Ming W, et al. (2016). Biochem Biophys Res Commun
- 37
Cobb LJ, et al. (2016). Aging (Albany NY)
- 38
Lee C, et al. (2015). Cell Metabolism
Primary Database
Primary Database
Also known as: MT-RNR1-derived peptide
View this compound in the Research Library →- Jun 21, 2026Abigail H.Verified
Clean COA via QR.
Secure packaging. Prompt shipping. Reliable.
- Jun 8, 2026Paul F.Verified
As part of our routine quality checks, I scanned the QR on arrival.
It linked to the correct COA for that lot, confirming the stated purity. The vial labeling was clear and matched the documentation. Packaging prevented any transit damage. The material appears well-suited for our research protocols.
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
