Melanocortin Research Peptide
PT-141 is studied as a probe of the brain's melanocortin signaling system. It acts centrally — through melanocortin receptors in the nervous system — and appears in preclinical models of melanocortin-receptor signaling.
Type
Synthetic peptide (cyclic heptapeptide)
Molecular formula
C50H68N14O10
Molecular weight
1,025.18 g/mol
CAS number
189691-06-3
Amino acids
7
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Modification
N-terminal acetylation; cyclic lactam (Asp-Lys bridge); contains norleucine and D-Phe; C-terminal carboxyl.
A cyclic heptapeptide lactam analogue of alpha-MSH in the melanocortin-receptor-ligand class; an agonist at melanocortin receptors including MC1R, MC3R and MC4R. Structurally the carboxyl-terminated relative of Melanotan II.
Research Focus
Studied in melanocortin-receptor pharmacology and central melanocortin-signaling research.
Lyophilized
-20°C, sealed, protected from light/moisture
stable months to years.
Reconstituted
2-8°C, up to ~weeks
aliquot and store -20°C for longer.
Avoid freeze-thaw; protect from light; the cyclic structure confers metabolic stability.
Reviews
Kingsberg SA, Simon JA. (2021). Expert Opin Pharmacother — Clinical-data review (HSDD population)
Giuliano F, et al. (2008). J Sex Med — Review of melanocortin receptors and sexual function
Molinoff PB, et al. (2006). Ann NY Acad Sci — Melanocortin-agonist pharmacology and early-development review
Clinical
Simon JA, et al. (2020). Obstet Gynecol — 52-week open-label Phase 3 extension, HSDD
Clayton AH, et al. (2020). J Womens Health — Pooled cardiovascular-safety analysis, RECONNECT studies
Kingsberg SA, et al. (2019). Obstet Gynecol — Replicate Phase 3 RECONNECT trials, premenopausal women with HSDD
Clayton AH, et al. (2016). J Sex Med — Phase 2b study in female sexual dysfunction
Diamond LE, et al. (2006). J Sex Med — Phase 2a crossover study in female sexual arousal disorder (intranasal)
Diamond LE, et al. (2004). Int J Impot Res — Phase 1/2 safety, PK and PD study in healthy men and erectile dysfunction
Primary research
Shadiack AM, et al. (2004). Pharmacol Biochem Behav — Female-rat sexual-behavior model (MC4R-dependent)
Also known as: PT 141
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
