BPC-157 + TB-500
A two-peptide research blend examined through connective-tissue, vascular, and epithelial model systems.
Molecular Profile
- Type
- Peptide blend
Components
BPC-157
- Molecular formula
- C62H98N16O22
- Molecular weight
- 1,419.5 g/mol
- CAS number
- 137525-51-0
- Sequence
- GEPPPGKPADDAGLV
TB-500 (N-acetylated heptapeptide fragment)
- Molecular formula
- C38H68N10O14
- Molecular weight
- 889.0 g/mol
- CAS number
- 885340-08-9
- Sequence
- Ac-LKKTETQ
Mechanism & Target Class
At the molecular level, this blend combines two structurally distinct peptides. BPC-157 is a 15-amino-acid peptide (GEPPPGKPADDAGLV) examined in indexed work using endothelial and fibroblast model systems, where readouts include tube-formation assays and phosphorylation measurements in cultured cells. TB-500 is characterized in peer-reviewed analytical work as an N-terminally acetylated heptapeptide, Ac-LKKTETQ, corresponding to a short actin-binding sequence motif within a larger endogenous peptide; related literature maps this sequence to actin-associated chemistry, cell-adhesion model systems, and migration-linked assays.
Storage & Handling
- Lyophilized
- Keep sealed, dry, and protected from light; general synthetic-peptide handling guidance recommends storage at −20 °C or colder.
- Handling
- Reconstituted peptide stability is sequence-dependent; moisture, repeated freeze-thaw cycles, strong alkaline conditions, and light exposure can reduce integrity. Component-specific stability for this exact two-peptide formulation was not specifically characterized in the sources reviewed.
Primary Database
References (19)
Reviews
1Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM (2025). HSS Journal
- 2
McGuire FP, et al. (2025). Current Reviews in Musculoskeletal Medicine
- 3
Ying Y, Lin C, Tao N, Hoffman RD, Shi D, Chen Z, Gao J (2023). Current Protein & Peptide Science
- 4
Seiwerth S, Brcic L, Vuletic LB, et al. (2021). Frontiers in Pharmacology
- 5
Gwyer D, Wragg NM, Wilson SL (2019). Cell and Tissue Research
Primary research
6ClinicalTrials.gov (2026). ClinicalTrials.gov
- 7
ClinicalTrials.gov (2026). ClinicalTrials.gov
- 8
ClinicalTrials.gov (2020). ClinicalTrials.gov
- 9
ClinicalTrials.gov (2015). ClinicalTrials.gov
- 10
Rahaman KA, Muresan AR, Min H, Son J, Han H-S, Kang M-J, Kwon O-S (2024). Journal of Chromatography B
- 11
Hsieh MJ, Lee CH, Chueh HY, Chang GJ, Huang HY, Lin Y, Pang JHS (2020). Scientific Reports
- 12
Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VHS, Pang JHS (2017). Journal of Molecular Medicine
- 13
Chang C-H, Tsai W-C, Hsu Y-H, Pang J-HS (2014). Molecules
- 14
Ho ENM, Kwok WH, Lau MY, Wong ASY, Wan TSM, Lam KKH, Schiff PJ, Stewart BD (2012). Journal of Chromatography A
- 15
Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P (2012). Drug Testing and Analysis
- 16
Chang C-H, Tsai W-C, Lin M-S, Hsu Y-H, Pang J-HS (2011). Journal of Applied Physiology
- 17
Sosne G, Qiu P, Goldstein AL, Wheater M (2010). FASEB Journal
- 18
Philp D, Huff T, Gho YS, Hannappel E, Kleinman HK (2003). FASEB Journal
- 19
Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zoricic I, Klicek R, Radic B, Nikolic I, Juric G, Mester M, Petek M, Sikiric P (2003). Journal of Orthopaedic Research
