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Signaling
A two-peptide research blend examined through connective-tissue, vascular, and epithelial model systems.
Reviewed by Dr. James Whitfield, PharmD · Published · Last reviewed · For research use only.
Peptide blend
Molecular formula
C62H98N16O22
Molecular weight
1,419.5 g/mol
CAS number
137525-51-0
Sequence
GEPPPGKPADDAGLV
Molecular formula
C38H68N10O14
Molecular weight
889.0 g/mol
CAS number
885340-08-9
Sequence
Ac-LKKTETQ
At the molecular level, this blend combines two structurally distinct peptides. BPC-157 is a 15-amino-acid peptide (GEPPPGKPADDAGLV) examined in indexed work using endothelial and fibroblast model systems, where readouts include tube-formation assays and phosphorylation measurements in cultured cells. TB-500 is characterized in peer-reviewed analytical work as an N-terminally acetylated heptapeptide, Ac-LKKTETQ, corresponding to a short actin-binding sequence motif within a larger endogenous peptide; related literature maps this sequence to actin-associated chemistry, cell-adhesion model systems, and migration-linked assays.
Lyophilized
Keep sealed, dry, and protected from light
general synthetic-peptide handling guidance recommends storage at −20 °C or colder.
moisture, repeated freeze-thaw cycles, strong alkaline conditions, and light exposure can reduce integrity. Component-specific stability for this exact two-peptide formulation was not specifically characterized in the sources reviewed.
Reviews
Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM (2025). HSS Journal
McGuire FP, et al. (2025). Current Reviews in Musculoskeletal Medicine
Ying Y, Lin C, Tao N, Hoffman RD, Shi D, Chen Z, Gao J (2023). Current Protein & Peptide Science
Reviews
Seiwerth S, Brcic L, Vuletic LB, et al. (2021). Frontiers in Pharmacology
Gwyer D, Wragg NM, Wilson SL (2019). Cell and Tissue Research
Primary research
ClinicalTrials.gov (2026). ClinicalTrials.gov
ClinicalTrials.gov (2026). ClinicalTrials.gov
ClinicalTrials.gov (2020). ClinicalTrials.gov
ClinicalTrials.gov (2015). ClinicalTrials.gov
Rahaman KA, Muresan AR, Min H, Son J, Han H-S, Kang M-J, Kwon O-S (2024). Journal of Chromatography B
Hsieh MJ, Lee CH, Chueh HY, Chang GJ, Huang HY, Lin Y, Pang JHS (2020). Scientific Reports
Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VHS, Pang JHS (2017). Journal of Molecular Medicine
Chang C-H, Tsai W-C, Hsu Y-H, Pang J-HS (2014). Molecules
Ho ENM, Kwok WH, Lau MY, Wong ASY, Wan TSM, Lam KKH, Schiff PJ, Stewart BD (2012). Journal of Chromatography A
Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P (2012). Drug Testing and Analysis
Chang C-H, Tsai W-C, Lin M-S, Hsu Y-H, Pang J-HS (2011). Journal of Applied Physiology
Sosne G, Qiu P, Goldstein AL, Wheater M (2010). FASEB Journal
Philp D, Huff T, Gho YS, Hannappel E, Kleinman HK (2003). FASEB Journal
Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zoricic I, Klicek R, Radic B, Nikolic I, Juric G, Mester M, Petek M, Sikiric P (2003). Journal of Orthopaedic Research
Research Use Only
These products are intended for research purposes only and are not for human consumption. Not FDA approved. Not intended to diagnose, treat, cure, or prevent any disease.
| Compound | Type | Molecular weight | CAS number |
|---|---|---|---|
| BPC-157 + TB-500This page | Peptide blend | — | — |
| PT-141 | Synthetic peptide (cyclic heptapeptide) | 1,025.18 g/mol | 189691-06-3 |
| Cardiogen | Synthetic linear tetrapeptide (short peptide bioregulator) | 489.5 g/mol | — |
| Cerebrolysin | Porcine brain-derived neuropeptide and amino-acid preparation (enzymatic hydrolysate; heterogeneous mixture) | Peptide fraction <10 kDa | 12656-61-0 |
| Cortagen | Synthetic linear tetrapeptide | 446.45 g/mol | — |
Comparison of laboratory reference specifications only. For research use only; not a therapeutic comparison.
Quality & methods