BPC-157 / TB-500 / KPV
A three-peptide research blend studied in preclinical cellular research models.
Molecular Profile
- Type
- Peptide blend
Components
BPC-157
- Molecular formula
- C62H98N16O22
- Molecular weight
- 1,419.5 g/mol
- CAS number
- 137525-51-0
- Sequence
- GEPPPGKPADDAGLV
TB-500 (full-length acetylated Thymosin Beta-4)
- Molecular formula
- C212H350N56O78S
- Molecular weight
- ~4,963 g/mol
- CAS number
- 77591-33-4
- Sequence
- Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
KPV
- Molecular formula
- C16H30N4O4
- Molecular weight
- 342.43 g/mol
- CAS number
- 67727-97-3
- Sequence
- Lys-Pro-Val
Mechanism & Target Class
A three-component formulation combining a gastric-juice-derived pentadecapeptide (BPC-157), a full-length Thymosin Beta-4-related actin-binding peptide (TB-500), and an alpha-MSH-derived tripeptide (KPV). The components are associated in the literature with distinct molecular contexts — VEGFR2/eNOS-related vascular signaling, intracellular G-actin sequestration, and PepT1 transport with NF-kB / MAPK signaling, respectively — and the blend has no single shared target.
Storage & Handling
- Lyophilized
- -20°C; protect from light; stable months desiccated.
- Handling
- Multi-peptide blend; component ratios vary by supplier; aliquot to avoid freeze-thaw.
References (29)
Reviews
1Vasireddi N, et al. (2025). HSS Journal
- 2
Jozwiak M, et al. (2025). Pharmaceuticals (Basel)
- 3
Narrative review (2025). Curr Rev Musculoskelet Med
- 4
Kleinman HK, Sosne G. (2016). Vitam Horm
- 5
Sikiric P, et al. (2014). Curr Pharm Des
- 6
Goldstein AL, et al. (2012). Expert Opin Biol Ther
- 7
Sikiric P, et al. (2011). Curr Pharm Des
- 8
Brzoska T, et al. (2010). Adv Exp Med Biol
- 9
Brzoska T, et al. (2008). Endocr Rev
- 10
Huff T, et al. (2003). Vitam Horm
Clinical
11ClinicalTrials.gov. ClinicalTrials.gov
- 12
ClinicalTrials.gov. ClinicalTrials.gov
- 13
ClinicalTrials.gov. ClinicalTrials.gov
- 14
ClinicalTrials.gov. ClinicalTrials.gov
- 15
ClinicalTrials.gov. ClinicalTrials.gov
Primary research
16He L, et al. (2022). Front Pharmacol
- 17
Hsieh MJ, et al. (2020). Sci Rep
- 18
Xiao B, et al. (2017). Mol Ther
- 19
Hsieh MJ, et al. (2017). J Mol Med (Berlin)
- 20
Cox HD, et al. (2017). Drug Test Anal
- 21
Merlin D, et al. (2016). Cell Mol Gastroenterol Hepatol
- 22
Chang CH, et al. (2014). Molecules
- 23
Xue B, et al. (2014). PNAS
- 24
Chang CH, et al. (2011). J Appl Physiol
- 25
Kumar S, Gupta S. (2011). PLoS One
- 26
Dalmasso G, et al. (2008). Gastroenterology
- 27
Kannengiesser K, et al. (2008). Inflamm Bowel Dis
- 28
Smart N, et al. (2007). Nature
- 29
Bock-Marquette I, et al. (2004). Nature
