Luvaminos

Epithalon

A short synthetic tetrapeptide studied in telomere biology, chromatin research, and pineal neuroendocrine models.

Quick answers

What is Epithalon?

Epithalon is a synthetic linear tetrapeptide of 4 amino acids with a molecular weight of 390.35 g/mol and the formula C14H22N4O9.

How much published research cites Epithalon?

The Luvaminos Epithalon record cites 28 published references, dated 1992 to 2025. Each is listed on this page with a link to its source.

Does Luvaminos test Epithalon, and where is the certificate?

Luvaminos does not currently stock Epithalon. Every peptide lot Luvaminos sells is tested by Freedom Diagnostics Testing, PLLC, an independent laboratory, and its certificate is published at luvaminos.com/coa under the lot number printed on the vial.

What modifications does Epithalon carry?

Epithalon: Free termini.

How is Epithalon powder stored?

Sealed Epithalon powder: −20°C desiccated and light-protected; −80°C for long-term storage. Hygroscopic short peptide; protect from light and moisture.

Molecular Profile

Type
Synthetic linear tetrapeptide
Molecular formula
C14H22N4O9
Molecular weight
390.35 g/mol
CAS number
307297-39-8
Amino acids
4
Sequence
Ala-Glu-Asp-Gly (AEDG)
Modification
Free termini.

Mechanism & Target Class

Epithalon (AEDG) is a four-residue peptide sufficiently small to enter the nucleus directly. Biophysical and molecular-docking work has examined interactions of the AEDG sequence with the DNA double helix and with linker histones H1/3 and H1/6, characterizing binding geometry and measuring chromatin-condensation state and nucleolar-organizer-region gene transcript levels as assay endpoints. The telomere biology literature has assayed hTERT gene expression and telomerase enzymatic activity in cell-culture models exposed to Epithalon; cancer-cell-line studies have additionally measured telomere dynamics through the alternative lengthening of telomeres (ALT) pathway. A separate body of work examines the peptide in neuroendocrine models, measuring melatonin synthesis and cortisol circadian-rhythm parameters in primate and human study designs.

Storage & Handling

Lyophilized
−20°C desiccated and light-protected; −80°C for long-term storage.
Handling
Hygroscopic short peptide; protect from light and moisture.

Primary Database

PubChem CID 219042 ↗

References (28)

  1. Reviews

    1

    Araj SK, et al. (2025). Int J Mol Sci

    DOI: 10.3390/ijms26062691PubMed 40141333

  2. 2

    Khavinson VKh, et al. (2021). Molecules

    DOI: 10.3390/molecules26227053

  3. 3

    Anisimov VN, Khavinson VKh. (2010). Biogerontology

    DOI: 10.1007/s10522-009-9249-8

  4. 4

    Khavinson VKh, et al. (2009). Bull Exp Biol Med

    DOI: 10.1007/s10517-009-0655-xPubMed 20016347

  5. 5

    Khavinson VKh. (2002). Neuroendocrinol Lett

    PubMed 12374906

  6. Clinical

    6

    Korkushko OV, et al. (2011). Bull Exp Biol Med

    DOI: 10.1007/s10517-011-1332-xPubMed 22451889

  7. 7

    Labunets IF, et al. (2007). Bull Exp Biol Med

    DOI: 10.1007/s10517-007-0159-yPubMed 18214303

  8. 8

    Korkushko OV, et al. (2006). Bull Exp Biol Med

    DOI: 10.1007/s10517-006-0365-zPubMed 17426848

  9. 9

    Korkushko OV, et al. (2004). Bull Exp Biol Med

    DOI: 10.1023/b:bebm.0000035139.31138.bfPubMed 15452611

  10. 10

    Korkushko OV, et al. (2004). Bull Exp Biol Med

    DOI: 10.1023/B:BEBM.0000038165.22074.e4PubMed 15455130

  11. 11

    Khavinson VKh, et al. (2002). Neuroendocrinol Lett

    PubMed 12195242

  12. Primary research

    12

    Al-Dulaimi S, et al. (2025). Biogerontology

    DOI: 10.1007/s10522-025-10315-xPubMed 40908429

  13. 13

    Gatta M, et al. (2025). Stem Cell Rev Rep

    DOI: 10.1007/s12015-025-10911-xPubMed 40493162

  14. 14

    Ullah S, et al. (2025). Life Sci

    DOI: 10.1016/j.lfs.2025.123381PubMed 39788414

  15. 15

    Yue X, et al. (2022). Aging (Albany NY)

    DOI: 10.18632/aging.204007

  16. 16

    Khavinson V, et al. (2020). Molecules

    DOI: 10.3390/molecules25030609

  17. 17

    Sinjari B, et al. (2020). Stem Cell Rev Rep

    DOI: 10.1007/s12015-019-09921-3PubMed 31677028

  18. 18

    Khavinson VKh, et al. (2019). Bull Exp Biol Med

    DOI: 10.1007/s10517-019-04664-0

  19. 19

    Vinogradova IA, et al. (2008). Bull Exp Biol Med

    DOI: 10.1007/s10517-008-0121-7PubMed 19110597

  20. 20

    Khavinson VKh, et al. (2004). Bull Exp Biol Med

    DOI: 10.1023/b:bebm.0000038164.49947.8cPubMed 15455129

  21. 21

    Khavinson VKh, et al. (2003). Bull Exp Biol Med

    DOI: 10.1023/A:1025493705728PubMed 12937682

  22. 22

    Khavinson VKh, et al. (2003). Bull Exp Biol Med

    DOI: 10.1023/A:1025497806636

  23. 23

    Anisimov VN, et al. (2003). Biogerontology

    DOI: 10.1023/A:1025114230714PubMed 14501182

  24. 24

    Anisimov VN, et al. (2002). Int J Cancer

    DOI: 10.1002/ijc.10570PubMed 12209581

  25. 25

    Anisimov VN, et al. (2002). Cancer Lett

    DOI: 10.1016/s0304-3835(02)00090-3

  26. 26

    Goncharova ND, et al. (2001). Bull Exp Biol Med

    DOI: 10.1023/a:1017928925177

  27. 27

    Khavinson VKh, et al. (2001). Neuroendocrinol Lett

    PubMed 11524632

  28. 28

    Anisimov VN, et al. (1992). Ann N Y Acad Sci

    DOI: 10.1111/j.1749-6632.1992.tb27436.xPubMed 1485734

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About Epithalon

What is Epithalon?

Epithalon is a short synthetic tetrapeptide studied in telomere biology, chromatin research, and pineal neuroendocrine models.

What are the molecular formula, molecular weight and CAS number of Epithalon?

Epithalon: molecular formula C14H22N4O9, molecular weight 390.35 g/mol and CAS number 307297-39-8.

What is the sequence of Epithalon?

Ala-Glu-Asp-Gly (AEDG).

How is Epithalon powder stored?

−20°C desiccated and light-protected; −80°C for long-term storage.