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For Research Purposes Only
Out of StockMolecular Profile
Molecular Profile
Type
Synthetic peptide (Thymosin Beta-4 related)
Molecular formula
C212H350N56O78S
Molecular weight
~4,963 g/mol
CAS number
77591-33-4
Amino acids
43
Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Modification
N-terminal acetylation. Two distinct molecules are marketed under this name: full-length Thymosin Beta-4 (Tβ4; 43 residues; CAS 77591-33-4) and the actin-binding fragment Ac-LKKTETQ (residues 17-23; CAS 885340-08-9). Most published in vivo and clinical research has examined the full-length peptide, not the short fragment; the two are studied as separate molecules.
Mechanism & Target Class
Mechanism & Target Class
Thymosin Beta-4 is the principal intracellular G-actin-sequestering peptide; the LKKTETQ motif is its actin-binding domain. It binds monomeric actin and modulates actin polymerization rather than acting through a cell-surface receptor.
Storage & Handling
Storage & Handling
Lyophilized
20°C
~24 months desiccated and protected from light.
Highly water-soluble; protect from light; aliquot; salt form affects exact mass.
References
References
Reviews
- 1
Kleinman HK, et al. (2023). Int Immunopharmacology
- 2
Sosne G, Berger EA. (2023). Int Immunopharmacol
Reviews
- 3
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- 4
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Kleinman HK, Sosne G. (2016). Vitam Horm
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Sosne G, Kleinman HK. (2015). Invest Ophthalmol Vis Sci
- 7
Morris DC, et al. (2012). Ann NY Acad Sci
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Goldstein AL, et al. (2012). Expert Opin Biol Ther
- 9
Crockford D, et al. (2010). Ann NY Acad Sci
- 10
Hannappel E. (2007). Ann NY Acad Sci
- 11
Goldstein AL, et al. (2005). Trends Mol Med
Clinical
- 12
Sosne G, et al. (2022). Int J Mol Sci
- 13
Sosne G, Ousler GW. (2015). Clin Ophthalmol
- 14
Sosne G, et al. (2015). Cornea
- 15
Ruff D, et al. (2010). Ann NY Acad Sci
- 16
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Primary research
- 26
Kim S, Choi J, Kwon J. (2023). Molecules
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Tan SH, et al. (2021). Theranostics
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Kim S, Kwon J. (2018). Sci Rep
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Li H, et al. (2018). J Gene Med
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Kim J, Jung Y. (2017). Sci Rep
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Hong Y, et al. (2017). Biochem Biophys Res Commun
- 32
Zhang J, et al. (2016). Neurobiol Dis
- 33
Cheng P, et al. (2014). Neuropharmacology
- 34
Conte E, et al. (2013). Eur J Clin Invest
- 35
Wang L, et al. (2012). Neurobiol Dis
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Xiong Y, et al. (2012). J Neurosurg
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Didry D, et al. (2012). EMBO J
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Esposito S, et al. (2012). Drug Test Anal
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Ho ENM, et al. (2012). J Chromatogr A
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Smart N, et al. (2011). Nature
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Morris DC, et al. (2010). Neuroscience
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Zhang J, et al. (2009). Neuroscience
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Smart N, et al. (2007). Nature
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Philp D, et al. (2007). Ann NY Acad Sci
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Philp D, et al. (2006). J Cell Physiol
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Bock-Marquette I, et al. (2004). Nature
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Philp D, et al. (2004). FASEB J
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Irobi E, et al. (2004). EMBO J
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Hertzog M, et al. (2004). Cell
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Philp D, et al. (2003). FASEB J
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Sosne G, et al. (2002). Exp Eye Res
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Grant DS, et al. (1999). Angiogenesis
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Malinda KM, et al. (1999). J Invest Dermatol
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Malinda KM, et al. (1997). FASEB J
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Weber A, et al. (1992). Biochemistry
Primary Database
Primary Database
Also known as: Thymosin beta-4 (full-length), Ac-LKKTETQ (fragment)
View this compound in the Research Library →- Jun 29, 2026Helen L.Verified
>99% purity per third-party COA.
QR verification successful. Secure packaging. Prompt shipping.
- Jun 16, 2026David W.Verified
had a question about this batch before ordering, support got back same...
had a question about this batch before ordering, support got back same day with the info, when it arrived the qr scanned to the exact coa and the lot matched what was on the vial, packaging was nice and secure, everything checked out
Research Use Only. All products sold by Luvaminos are intended solely for in vitro research and laboratory use by qualified professionals. They are not approved by the FDA and are not intended for human or animal consumption, therapeutic use, or diagnostic purposes. By purchasing, you confirm you are a licensed researcher or institution and accept full responsibility for compliance with all applicable laws and regulations.
